Blood and Wine was especially tragic; I sympathized with Dettlaff and his pain, and Syanna was a terrible person. But preventing Detlaff from killing Syanna for using him leads to him attacking Geralt, who has to defend himself. Regis understands why you had to kill Dettlaff, but he still loved him like a brother; the death of Dettlaff leaves him feeling terribly alone. There isn’t any way to end the bloodshed; everyone is hell-bent on destroying themselves.
I’m going to add a choice here:
In honor of the late, great Steve Albini, Kerosene, by his band Big Black. It’s been covered by a few bands, but no one has managed the harsh, nihilistic electro-punk feel of the original.