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Women have enough problems with unwanted male interaction, not to mention so many lies about women’s anatomy. This makes it so much worse.
In this hypothetical, men switch from having a sexual interest in women 52/52 weeks a year to 4/52 weeks a year. I would expect a >92% reduction in “unwanted male interaction”.
My first thought (which probably isn’t the best method, but I’ve done similar before) is an Arduino between the mouse and the system. The Arduino normally just passes the mouse commands to the system, but it listens for the button and blocks movement if it sees the button press.
Because it’s all done in hardware, this method would be system-agnostic. You could plug it into anything.
I used a Teensy 3.6 for a similar project.